Ultrasensitive Determination of Tetrabromobisphenol A by Covalent Organic Framework Based Solid Phase Microextraction Coupled with Constant Flow Desorption Ionization Mass Spectrometry

Rapid detection of ultratrace pollutants in complex matrixes is a great challenge for studying their environmental behaviors and impacts. In this work, a method is developed by combining covalent organic framework(COF) based solid phase microextraction(SPME) with constant flow desorption ionization mass spectrometry for rapid detection of trace tetrabromobisphenolA (TBBPA) in multiple water media. The limits of detection and qualification are 0.92 and 3.1 ng L–1 for TBBPA, respectively. The linear range is between 0.01 and 10 μg L–1 (R2 = 0.9992), and the relative standard deviations with single fiber and multiple fibers are 6.4% and 6.7% (0.1 μg L–1, n = 9), respectively. The detection of nanogram per liter levels of TBBPA in tap water, river water, seawater, and beverage can be achieved in 7 min.