Enhanced production of Th1- and Th2-type antibodies and induction of regulatory T cells in mice by oral administration of Cyclopia extracts with similar phenolic composition to honeybush herbal tea

Abstract Immune-regulating activity of Cyclopia subternata and C. genistoides extracts (honeybush tea) in vitro, using a murine cell culture, merited investigation of their immune-regulating functions in vivo. Oral administration of the extracts and ovalbumin (OVA) to OVA specific-T cell receptor transgenic mice (DO11.10) significantly (P