Tolerance Dependent on Timing/Amount of Antigen-Dose in an Asymmetric Idiotypic Network

Physiological experiments demonstrate establishment of immunological tolerance is controlled by dose-timing and dose-amount of an antigen. My previous study reproduced the tolerance dependent on doso-timing of an antigen in a two Bcell clones network model with an asymmetric Bcell-Bcell interaction. This study first clarifies its mechanism using a dynamical system technique:nullcline analysis. Next, this study proposes a three Bcell clones network model with the same style of Bcell-Bcell interaction, and shows the model simulation can reproduce the tolerance dependent on dose-amount of an antigen: high and low zone tolerance. The success of this reproduction is worthy of attention. Because theoretical studies based on the traditional symmetric immune network modeling scheme have not been able to reproduce it well. This study would teach us the renewed recognition of asymmetric immune network modeling scheme.