5-HT7 receptor signaling: improved therapeutic strategy in gut disorders
2014
Serotonin (
5-hydroxytrytamine;
5-HT) is most commonly known for its role as a neurotransmitter in the central nervous system. However, the majority of the body’s
5-HT is produced in the gut by enterochromaffin (EC) cells. Alterations in
5-HT signaling have been associated with various gut disorders including inflammatory bowel disease (IBD),
irritable bowel syndrome(IBS) and enteric infections. Recently, our studies have identified a key role for
5-HT in the pathogenesis of experimental colitis.
5-HT7 receptorsare expressed in the gut and very recently, we have shown evidence of
5-HT7 receptorexpression on intestinal immune cells and demonstrated a key role for
5-HT7 receptorsin generation of experimental colitis. This review summarizes the key findings of these studies and provides a comprehensive overview of our current knowledge of the
5-HT7 receptorin terms of its pathophysiological relevance and therapeutic potential in intestinal inflammatory conditions, such as IBD.
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