Serum fibroblast growth factor 21 level is increased in pre-eclampsia patients: Association with blood pressure and lipid profile.

BACKGROUND Pre-eclampsia (PE) is dangerous complication, which leads to adverse pregnancy outcomes. AIMS The study was to explore the correlation between serum level of fibroblast growth factor (FGF) 21 and PE. METHODS A total of 80 cases were involved in this study containing PE group (49 cases) and control group (31 cases, normal pregnancy). PE group was divided into early-onset PE (EOPE) and late-onset PE (LOPE). Serum level of FGF21 and biochemical parameters were measured before delivery. RESULTS Maternal serum FGF21 level was higher in PE especially in EOPE than that in control groups (P < 0.05). In PE patients, serum FGF21 level was positively correlated with mean arterial pressure, diastolic blood pressure and low-density lipoprotein cholesterol (P < 0.05). Levels of FGF21, uric acid and low-density lipoprotein cholesterol were risk factors for PE. CONCLUSION Maternal serum FGF21 level in PE particularly in EOPE was higher and was associated with blood pressure and lipid profile.