Association of PD-L1 gene rs4143815 C>G polymorphism and human cancer susceptibility: A systematic review and meta-analysis

Abstract Programmed death ligand 1( PD-L1) mediated immune escape play important roles in the development of cancer. The gene polymorphism of PD-L1, in particular rs4143815 C > G, has been associated with the cancer risks, but with conflicting results. Therefore, this meta-analysis was aimed to assess the association between rs4143815 C > G and cancer susceptibility. A systematic literature search was performed to select the studies and the pooled odds ratio (OR) with 95% confidence interval (CI) was used to evaluate the strength of association. Eleven eligible studies containing 3711 cases and 3704 controls were enrolled in the meta-analysis. The results suggested that there is a strong association between rs4143815 C > G and the cancer risks (G vs. C: OR = 1.386, 95% CI: 1.132–1.696, p = 0.002; GG vs. CG + CC: OR = 1.843 95% CI: 1.300–2.613, p = 0.002; GG + CG vs. CC: OR = 1.280, 95% CI: 1.040–1.576, p = 0.020). Subgroup analysisbased on cancer type suggested that PD-L1rs4143815 C > G might increase the susceptibility to gastric cancer (G vs. C: OR = 1.842, 95% CI: 1.403–2.418, p   G might have higher risks of HCC (GG vs. CG + CC: OR = 2.226 95% CI: 1.562–3.172, p   G might confer an increased cancer risk, indicating this SNP may contribute to the pathogenesis of cancer and might be used as a potential biomarker to predict the susceptibility to cancer.