Specific targeting of PDGFRβ in the stroma inhibits growth and angiogenesis in tumors with high PDGF-BB expression

Maria Tsioumpekou,Sara I. Cunha,Haisha Ma,Aive Åhgren,Jessica Cedervall,Anna-Karin Olsson,Carl-Henrik Heldin,Johan Lennartsson

Specific targeting of PDGFRβ in the stroma inhibits growth and angiogenesis in tumors with high PDGF-BB expression

2020

Maria Tsioumpekou
Sara I. Cunha
Haisha Ma
Aive Åhgren
Jessica Cedervall
Anna-Karin Olsson
Carl-Henrik Heldin
Johan Lennartsson

PDGF-BB/PDGFR beta signaling plays an important role during vascularization by mediating pericyte recruitment to the vasculature, promoting the integrity and function of vessels. Until now it has n ...

Keywords:

Cancer research
Platelet-derived growth factor receptor
Molecular biology
Angiogenesis
Stroma
Biology
PDGFR beta
Cell and molecular biology
tumor growth
Pericyte

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