Lipid Peroxidation and Cardiac Troponin T Release during Routine Cardiac Surgery

Myocardial injury after cardiac surgery with cardiopulmonary bypassmay be related to free oxygen radical-induced lipid peroxidation. The purpose of this study was to monitor perioperative changes of cardiac troponin tand malondialdehydeas an indicator of lipid peroxidation in patients who underwent routine cardiac operation and had no signs of perioperative myocardial infarction. Patients with thoracic surgery alone served as controls. We studied 20 patients with cardiopulmonary bypass(CPB) and 9 patients with other thoracic operations. Serum troponin t, malondialdehyde, myoglobin, creatine kinase (CK) including CK-MB isoenzyme levels were monitored before CPB, immediately after cessation of CPB, 20 and 44 h after CPB. Patients with signs of myocardial infarction before or up to 44 h after surgery were excluded. Of 20 patients with CBP, 18 patients showed a significant increase of troponin tand 16 patients had elevated malondialdehydeserum levels following CPB. Troponin tserum values were raised immediately after CPB to 0.60 ± 0.12 µg/l and increased further to 0.90 ± 0.17 µg/l after 44 h (p