Empirical likelihood inference for longitudinal data with covariate measurement errors: an application to the LEAN study.

Measurement errors usually arise during the longitudinal data collection process and ignoring the effects of measurement errors will lead to invalid estimates. The Lifestyle Education for Activity and Nutrition (LEAN) study was designed to assess the effectiveness of intervention for enhancing weight loss over 9 months. The covariates systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured at baseline, month 4, and month 9. At each assessment time, there were two replicate measurements for SBP and DBP, where the replicate measurement errors of SBP and DBP respectively followed different distributions. To account for the distributional difference of replicate measurement errors, a new method for the analysis of longitudinal data with replicate covariate measurement errors is developed based on the empirical likelihood method. The asymptotic properties of the proposed estimator are established under some regularity conditions and the confidence region for the parameters of interest can be constructed based on the chi-squared approximation without estimating the covariance matrix. Additionally, the proposed empirical likelihood estimator is asymptotically more efficient than the estimator of Lin et al. [Lin, H., Qin, G., Zhang, J., Zhu, Z., Comput Stat Data Anal, 104-112, 121, 2018]. Extensive simulations demonstrate that the proposed method can eliminate the effects of measurement errors in the covariate and has a high estimation efficiency. The proposed method indicates the significant effect of the intervention on BMI in the LEAN study.