Co-culture of Umbilical Cord Mesenchymal StemCells and Bovine Mammary Epithelial Cells RestrainsApoptosis

The goal of the present study is to investigate the capacity of co-cultured Umbilical Cord Mesenchymal Stem Cells (UC-MSCs) and BMECs to restrain BMECs apoptosis. In the current study, the Insulin Like Growth Factor-I (IGF-I) expression, cell proliferation, and apoptosis-related gene expression were evaluated between monoculture and co-culture systems. Meanwhile, the signal pathways related to apoptosis were examined to analyze the potential anti- apoptotic effects that co-culturing with UC-MSCs has on BMECs.