Cytotoxic Phenolic Compounds from Fruit Glandular Trichomes of Macaranga tanarius

2019
A new flavonoid, macatanarin D (1), together with five known stilbenes (2-6), was isolated from fruit glandular trichomesof Macaranga tanarius. Their structures were elucidated on the basis of spectroscopic methods and through comparison with data reportedin the literature. All isolated compounds were evaluated for their cytotoxicactivities against KB and MCF-7cell lines. Compounds 3, 4, and 5 showed the strongest activities against both cell lines with IC50values in the range of 0.03–0.12 μM, and compound 2 only showed a significant cytotoxicityagainst KB cell line ( IC50 = 0.26 μM) and a moderate cytotoxicityagainst MCF-7( IC50 = 10.4 μM). Compounds 1 and 6 showed weak cytotoxicactivities against KB cell line with IC50values of 29.3 and 24.7 μM, respectively.
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