UHPLC-QTOF/MS-based metabolomics investigation for the protective mechanism of Danshen in Alzheimer’s disease cell model induced by Aβ1–42

Introduction Alzheimer’s disease (AD) is a chronic neurodegenerative disorder with neither definitive pathogenesis nor effective therapy so far. Danshen, the dried root and rhizomeof Salvia miltiorrhiza Bunge, is used extensively in Alzheimer’s disease treatment to ameliorate the symptoms, but the underlying mechanism remains to be clarified.