Effects of starvation and Ca++ on glucose-induced accumulation of cyclic 3′,5′-AMP in pancreatic islets

Exposure to glucose in the presence of 3-isobutyl-1-methylxanthine leads to accumulation of cAMP in islets microdissected fromob/ob-mice. This process is dependent on extracellular Ca++ but differs markedly from the glucose action on insulin release in the same in vitro system in disappearing after 18 h of starvation.