Personality: Neurobehavioural Foundation and Pharmacological Protocols
2014
Personality represents the structuring of human behavior into major
traitsthat reflect the activity of (1) motivational-emotional systems and (2) their underlying neurobiological networks. There is consensus on the existence of four major
traits: extraversion,
neuroticism, social closeness or
agreeableness, and constraint or
conscientiousness. We describe the psychological features of these four
traits, and how pharmacological protocols have aided in defining their underlying neurobiology. Discussion of the relation of dopamine (DA), serotonin (5-HT), corticotropinreleasing hormone (CRH), and mu-
opiatefunctioning within specific brain regions to the four major
traitsis provided.
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