Constrained model-predictive thermal dose control for MRI-guided ultrasound thermal treatments

Ultrahigh resolution OCT using broadband light sources achieves improved axial image resolutions of ~2-3 um compared to standard 10 um resolution OCT used in current commercial instruments. High-speed OCT using Fourier/spectral domain detection enables dramatic increases in imaging speeds. 3D OCT retinal imaging is performed in human subjects using high-speed, ultrahigh resolution OCT, and the concept of an OCT fundus image is introduced. Three-dimensional data and high quality cross-sectional images of retinal pathologies are presented. These results show that 3D OCT may be used to improve coverage of the retina, precision of cross-sectional image registration, quality of cross-sectional images, and visualization of subtle changes in retinal topography. 3D OCT imaging and mapping promise to help elucidate the structural changes associated with retinal disease as well as to improve early diagnosis and monitoring of disease progression and response to treatment.