Life without brain serotonin: Reevaluation of serotonin function with mice deficient in brain serotonin synthesis

Abstract Tryptophan hydroxylase(TPH) is a rate limitingenzyme in the synthesis of serotonin (5-HT), a monoamine which works as an autacoidin the periphery and as a neurotransmitter in the central nervous system. In 2003 we have discovered the existence of a second Tph gene, which is expressed exclusively in the brain, and, therefore, is responsible for the 5-HT synthesis in the central nervous system. In the following years several research groups have independently generated Tph2-deficient mice. In this review we will summarize the data gained from the existing mouse models with constitutive or conditional deletion of the Tph2gene, focusing on biochemical, developmental, and behavioral consequences of Tph2-deficiency.