Structural and functional MRI correlates of T2 hyperintensities of brain white matter in young neurologically asymptomatic adults

Objectives Although white matter hyperintensities(WMHs) are quite commonly found incidentally, their aetiology, structural characteristics, and functional consequences are not entirely known. The purpose of this study was to quantify WMHs in a sample of young, neurologically asymptomatic adults and evaluate the structural and functional correlations of lesion load with changes in brain volume, diffusivity, and functional connectivity.