Diastereo- and Enantioselective Assembly of Spirooxindole Tetrahydroquinoline Skeletons through Asymmetric Binary Acid Catalyzed Hydride Transfer–Cyclization
2015
An efficient binary acid catalyzed asymmetric intramolecular tandem 1,5-hydride transfer/ring-closure reaction was achieved. The process is catalyzed by the combination of a chiral spirocyclic phosphoric acid and magnesium chloride to afford structurally diverse spirooxindole tetrahydroquinolines in good yields with high diastereo- and enantioselectivities.
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