Using Human Plasma as an Assay Medium in Caco-2 Studies Improves Mass Balance for Lipophilic Compounds

Kasiram Katneni,Thao Pham,Jessica Saunders,Gong Chen,Rahul T. Patil,Karen L. White,Nada Abla,Francis Chi Keung Chiu,David M. Shackleford,Susan A. Charman

Using Human Plasma as an Assay Medium in Caco-2 Studies Improves Mass Balance for Lipophilic Compounds

2018

Kasiram Katneni
Thao Pham
Jessica Saunders
Gong Chen
Rahul T. Patil
Karen L. White
Nada Abla
Francis Chi Keung Chiu
David M. Shackleford
Susan A. Charman

Purpose To examine the utility of human plasma as an assay medium in Caco-2 permeability studies to overcome poor mass balance and inadequate sink conditions frequently encountered with lipophilic compounds.

Keywords:

Biochemistry
Caco-2
Chromatography
Chemistry
Sink (computing)
human plasma
Permeability (electromagnetism)
Acceptor
Plasma
Monolayer
Transporter

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