Single-molecule DNA sequencing of acute myeloid leukemia and myelodysplastic syndromes with multiple TP53 alterations
2018
Although the frequency of TP53 mutations in
hematologic malignanciesis low, these mutations have a high clinical relevance and are usually associated with poor prognosis. Somatic TP53 mutations have been detected in up to 73.3% of cases of acute
myeloid leukemia(AML) with complex karyotype and 18.
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