A case of 10q trisomy syndrome with cleft palate

An extremely rare case of 10q trisomysyndrome with cleft palateis presented. A 1-month-old girl with characteristic facial features was referred to our clinic for treatment of cleft palate. Her medical historyincluded congenital heart disease, hydrocephaly, and cleft palate. Chromosomal examination revealed a karyotype of 46, XX, -1, +der (1) t (1; 10)(q44; q24.3) mat. A diagnosis of 10q trisomysyndrome was made. She received palatoplastyfor cleft palateat the age of 2 years and 5 months. The postoperative course was uneventful. One year 5 months after surgery, body weight had increased favorably and there was no food leakage from the nostrils, but her speech had not sufficiently improved.