Longitudinal Psychiatric Symptoms in Prodromal Huntington's Disease: A Decade of Data

Objective:Psychiatric symptoms are a significant aspect of Huntington’s disease, an inherited neurodegenerative illness. The presentation of these symptoms is highly variable, and their course does not fully correlate with motor or cognitive disease progression. The authors sought to better understand the development and longitudinal course of psychiatric manifestations in individuals who carry the Huntington’s disease mutation, starting from the prodromal period prior to motor diagnosis.Method:Longitudinal measures for up to 10 years of psychiatric symptoms from the Symptom Checklist–90–Revised were obtained from 1,305 participants (1,007 carrying the Huntington’s disease mutation and 298 without [classified as controls]) and 1,235 companions enrolled in the Neurobiological Predictors of Huntington’s Disease (PREDICT-HD) study. Participants with the mutation were stratified into three groups according to probability of motor diagnosis within 5 years. Using linear mixed-effects regression models, differen...