SAT0683 A north-south worldwide gradient in systemic activity of primary sjÖgren syndrome: increased severe disease in patients from southern countries

Objectives To analyse the influence of geolocationon the clinical systemic presentation of primary Sjogren syndrome(SjS) at diagnosis. Methods The Big Data Sjogren Project Consortium is an international, multicentre registry created in 2014. Centres were classified by continent, with an additional north-south sub-classification according to latitude (>or or or Results The highest baseline ESSDAI scores were reported from Southern vs Northern countries in Europe (7.2 vs 4.6, p Conclusions This study provides the first evidence for a strong influence of geolocationon the systemic phenotype of primary SjS at diagnosis. Geographical determinants should be considered as key variables when systemic diseaseis scored. Disclosure of Interest None declared