Development of a Scalable Synthesis of the Small Molecule TGFβR1 Inhibitor BMS-986260

Muthalagu Vetrichelvan,Souvik Rakshit,Sathishkumar Chandrasekaran,Karthikeyan Chinnakalai,Chetan Padmakar Darne,Dyamanna Doddalingappa,Indasi Gopikumar,Anuradha Gupta,Arun Kumar Gupta,Ananta Karmakar,Thirumalai Lakshminarasimhan,David K. Leahy,Senthil Palani,Vignesh Radhakrishnan,Richard Rampulla,Antony Savarimuthu,Varadharajan Subramanian,Upender Velaparthi,Jayakumar Sankara Warrier,Martin D. Eastgate,Robert M. Borzilleri,Arvind Mathur,Rajappa Vaidyanathan

Development of a Scalable Synthesis of the Small Molecule TGFβR1 Inhibitor BMS-986260

2020

A scalable route to the small molecule TGFβR1 inhibitor BMS-986260 (1) was developed. This alternative approach circumvented the purification of intermediates by column chromatography and provided ...

Keywords:

Small molecule
Chemistry
Column chromatography
Organic chemistry
TosMIC

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