Impairment of Left and Right Ventricular Longitudinal Strain in Asymptomatic Children with Type 1 Diabetes

Abstract Aim The relationship between type 1 diabetes (T1DM) and cardiac function in children is not well established. The purpose of this study was to investigate whether children and adolescents with T1DM present early asymptomatic abnormalities of left ventricular (LV)and right ventricular (RV) function. In addition, we evaluated the relationship of any such abnormalities with glycemic control and diabetes duration. Methods This was a prospective study. Standard echocardiography, tissue Doppler imaging, and two-dimensional strain analysis were performed prospectively in 52 children with T1DM. The results were compared with those from 52 healthy children matched for age and sex. Results There were no significant differences between the two groups in LV ejection fraction or RV systolic function. There was a difference between the two study groups in transtricuspid flow: the E-wave and A-wave velocities were significantly higher in the diabetic group. Left ventricular Global longitudinal strain(LV GLS) was significantly lower in T1DM children (−20.01 ± 1.86% vs. −22.99 ± 0.98%, respectively; P Conclusions Our findings suggest that LV GLS and RV FWLSare impaired in children with T1DM and that the decrease in LV GLS is correlated with diabetes duration and HbA1c levels.