Adult type 3 Gaucher disease as manifestation of R463C/Rec Nci I mutation: first reported case in the world literature.
2013
Gaucher disease is the most common
lysosomal storage disorder. It is autosomal recessive in nature and results from mutations in the GBa gene coding for acid
beta glucosidase. It is classified into three types based on CNS involvement and its severity. Type 3, or chronic neuronopathic Gaucher disease, generally has an onset in childhood and by definition, includes all patients with any form of neurologic involvement who have survived the first few years of life. Here we present a 36 year old male patient presenting with
hip painshowing bilateral
avascular necrosisof femoral head with massive splenomegaly and on evaluation, showed mental retardation, seizures, bilateral vertical and
horizontal gaze palsiesand eventually turned out to be type 3b Gaucher disease. This is the first case of Type 3 Gaucher disease being reported from India with mutation analysis and only case of Type 3 Gaucher disease in
world literatureshowing R463C/Rec Nci
I mutation.
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