Targeting subjects at high-risk of melanoma.

: The current strategies for early diagnosis result at the moment insufficient to make further progresses in the fight against the melanoma. Reaching people not reached by screening activity yet is necessary for reducing mortality from this tumor. The well-known risk factors are still effective, but they have to be implemented by other variables at risk, like sex and age. People aged over 50 years old should be considered at risk, independently from other features. Renewed messages should be addressed to population and general practitioners. In this paper the old and new evidences on main risk factors will be analyzed and supported by the evidences of the literature.