Erbliches Endometrium- und Ovarialkarzinom bei Patientinnen mit Lynch-Syndrom

Both endometrial cancer and ovarian cancer can be part of Lynch syndrome/HNPCC. In this case patients also have an increased risk of developing colon cancer or cancer of other organs. Therefore, cancer screening can only be provided using an interdisciplinary clinical setting in these high-risk individuals and their families. Clinical aspects and the genetic background of Lynch syndrome/HNPCC are outlined. Screening recommendations as well as genetic counselling and testing are described in this review.