Do oestrogens induce chromosome specific aneuploidy in vitro, similar to the pattern of aneuploidy seen in breast cancer?
2008
Abstract The study was concerned with investigating the specific effects of non-DNA reactive oestrogens at low “biologically relevant” doses and the causative role they may play in breast cancer through inducing
aneuploidy. A review of previous studies identified a non-random pattern of
aneuploidyseen in breast cancers. This information was used to select those chromosomes that undergo copy number changes in breast cancer and chromosomes that appear stable. A panel of
centromericspecific probes were selected and
centromericspecific fluorescence in situ hybridisation (FISH) was carried out on the human lymphoblastoid cell line, AHH-1, which had been pre-treated with the chemical
aneugens17-β oestradiol,
diethylstilbestrol(DES) and bisphenol-A (BP-A). The results suggest that oestrogens may play a causative role in breast cancer by inducing a
specific patternof
aneuploidysimilar to that seen in breast carcinomas. 17-β oestradiol appears to induce changes most similar to those seen in
breast tumours, BP-A induces the same pattern but at a lower frequency and DES appears to be less chromosome specific in its act.
Keywords:
-
Correction
-
Source
-
Cite
-
Save
65
References
16
Citations
NaN
KQI