SNS-314, a pan-Aurora kinase inhibitor, shows potent anti-tumor activity and dosing flexibility in vivo
2010
Purpose The Aurora family of serine/
threoninekinases (Aurora-A, Aurora-B, and Aurora-C) plays a key role in cells
orderlyprogression through
mitosis. Elevated expression levels of
Aurora kinaseshave been detected in a high percentage of melanoma, colon, breast, ovarian, gastric, and
pancreatic tumors. We characterized the biological and pharmacological properties of SNS-314, an ATP-competitive, selective, and potent inhibitor of
Aurora kinases.
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