The D Domain of LRRC4 anchors ERK1/2 in the cytoplasm and competitively inhibits MEK/ERK activation in glioma cells
2016
Background As a well-characterized key player in various
signal transductionnetworks,
extracellular-signal-regulated kinase(ERK1/2) has been widely implicated in the development of many malignancies. We previously found that
Leucine-rich repeatcontaining 4 (LRRC4) was a tumor suppressor and a negative regulator of the ERK/MAPK pathway in glioma tumorigenesis. However, the precise molecular role of LRRC4 in ERK signal transmission is unclear.
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