First Contact: serum amyloid A and pattern recognition in Th2 immunity.

Research over the past century has advanced our understanding of allergic airway disease, revealing its immunological underpinnings and enabling the development of therapeutics to manage disease. Atopic diseases in the lung are mediated primarily by T helper 2(Th2) cells, specific-IgE, and eosinophils, members of a canonical Type 2 immune response. Recent seminal research has provided extraordinary clarity surrounding the cells and molecules that launch the allergic cascade. However, the most upstream sensors which initiateType 2 immunity remain poorly understood.