Effective mismatch repair depends on timely control of PCNA retention on DNA by the Elg1 complex

ACKNOWLEDGEMENTS We thank Richard Kolodner and Eric Alani for strains and plasmids. We thank Anne Donaldson, Alexander Lorenz and Catherine Johnson from University of Aberdeen for careful reading of the manuscript. We thank Annabelle Duff and Veronika Petrova for assisting with the mutation rateassays, and Duru Cosar for assisting with crystal structure analysis. We appreciate assistance from staff of the Microscopy and Histology Core Facility and the qPCR facility at the University of Aberdeen. FUNDING Medical ResearchCouncil (MRC) Career DevelopmentFellowship [L019698/1 to T.K.]; American Cancer Society Research Scholar Award [Grant #440685 to B.A.K.]; National Institute of General Medical Sciences [R01 GM127776 to B.A.K.]; National Institutes of Health grant [R01 GM106060 to V.L.]. Swiss National Science Foundation Postdoc Mobility Fellowship (to C.G.). Funding for open access charge: Medical ResearchCouncil via University of Aberdeen Open Access Fund.