Practical Synthesis of (3aR, 9bR)-8-Fluoro-7-(perfluoropropan-2-yl)-9b-(phenylsulfonyl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole: An Advanced Intermediate to Access the RORγt Inverse Agonist BMT-362265

Ananta Karmakar,Roshan Y. Nimje,Arundutt Silamkoti,Manivel Pitchai,Mushkin Basha,Christuraj Singarayer,Duraisamy Ramasamy,G.T. Venkatesh Babu,Ramesh Samikannu,Srinath Subramaniam,Prakash Anjanappa,Muthalagu Vetrichelvan,Hemantha Kumar,Amol G. Dikundwar,Anuradha Gupta,Arun Kumar Gupta,Richard Rampulla,T. G. Murali Dhar,Arvind Mathur

Practical Synthesis of (3aR, 9bR)-8-Fluoro-7-(perfluoropropan-2-yl)-9b-(phenylsulfonyl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole: An Advanced Intermediate to Access the RORγt Inverse Agonist BMT-362265

2021

Ananta Karmakar
Roshan Y. Nimje
Arundutt Silamkoti
Manivel Pitchai
Mushkin Basha
Christuraj Singarayer
Duraisamy Ramasamy
G.T. Venkatesh Babu
Ramesh Samikannu
Srinath Subramaniam
Prakash Anjanappa
Muthalagu Vetrichelvan
Hemantha Kumar
Amol G. Dikundwar
Anuradha Gupta
Arun Kumar Gupta
Richard Rampulla
T. G. Murali Dhar
Arvind Mathur

A practical and scalable route to (3aR, 9bR)-8-fluoro-7-(perfluoropropan-2-yl)-9b-(phenylsulfonyl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole 10, an advanced intermediate en route to the synthesis o...

Keywords:

Stereochemistry
Indole test
Tetralone
Inverse agonist
RAR-related orphan receptor gamma
Chemistry

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