Bacterial MgrB peptide activates chemoreceptor Fpr3 in mouse accessory olfactory system and drives avoidance behaviour
2019
Innate immune
chemoreceptorsof the
formyl peptide receptor(Fpr) family are expressed by vomeronasal
sensory neurons(VSNs) in the accessory
olfactory system. Their biological function and coding mechanisms remain unknown. We show that mouse Fpr3 (Fpr-rs1) recognizes the core peptide motif f-MKKFRW that is predominantly present in the signal sequence of the bacterial protein MgrB, a highly conserved regulator of virulence and antibiotic resistance in
Enterobacteriaceae. MgrB peptide can be produced and secreted by bacteria, and is selectively recognized by a subset of VSNs. Exposure to the peptide also stimulates VSNs in freely behaving mice and drives innate avoidance. Our data shows that Fpr3 is required for neuronal
detectionand
avoidanceof peptides derived from a conserved master virulence regulator of
enteric bacteria. The role of
chemoreceptorson vomeronasal neurons are not fully understood. Here the authors show that in mice, the vomeronasal
chemoreceptorFpr3 responds to peptides from the bacterial MgrB protein, and that exposure to these peptides drives an
avoidance response.
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