Host, disease, and antiretroviral factors are associated with normalization of the CD4:CD8 ratio after initiating antiretroviral therapy

Brinda Subbarayal, PhD* Dirk Schiller, PhD* Christian M€ obs, PhD Wolfgang Pf€ utzner, MD Beatrice Jahn-Schmid, PhD Barbara Gepp, MSc Heimo Breiteneder, PhD Stefan Vieths, PhD Barbara Bohle, PhD From the Department of Pathophysiology and Allergy Research and Christian Doppler Laboratory for Immunomodulation, Medical University of Vienna, Vienna, Austria; the Division of Allergology, Paul-Ehrlich-Institut, Langen, Germany; and the Department of Dermatology and Allergology, Philipps University Marburg, Marburg, Germany. E-mail: barbara.bohle@meduniwien.ac.at. *These authors contributed equally to this work. This study was supported by the Christian Doppler Laboratory for Immunomodulation and the Austrian Science Fund, project SFB F4610 and F4608. Disclosure of potential conflict of interest: C. M€obs has received research and travel support from the German Research Foundation. W. Pf€utzner has received research and travel support from the German Research Foundation; is on the ALK-Abell o advisory board on insect venom allergy and house dust mite allergy; and has received lecture fees from Novartis and ALK-Abell o. B. Jahn-Schmid and H. Breiteneder have received research support from the Austrian Science Fund. S. Vieths has received consultancy fees from the Food Allergy Resource and Research Program, Lincoln, Neb; has received honorarium from the Medical University of Vienna for evaluating a PhD thesis; has received research support from Monsanto Company; has received lecture fees from the American Academy of Allergy, Asthma & Immunology, Deutsche Dermatologische Gesellschaft, the Spanish Society of Allergy and Clinical Immunology, Westdeutsche Arbeitsgemeinschaft f€ur p€adiatrische Pneumologie und Allergologie e.V., K€oln, Germany, Gesellschaft f€ur p€adiatrische Allergologie und Umweltmedizin, and € Arzteverband Deutscher Allergologen; received royalties from Schattauer Allergologie Handbuch and Elsevier Nahrungsmittelaller-gien und Intoleranzen; has received travel support from the German Research Foundation, the Federal Institute for Risk Assessment, the Austrian Society for Allergology and Immunology, the European Directorate for the Quality of Medicines and Health Care, the European Academy of Allergy and Clinical Immunology, the World Allergy Organization, Association Mon egasque pour le Perfectionnement des Connaissances des M edicins, the Federal Office of Consumer Protection and Food Safety, the German Chemical Society, the Austrian Society for Dermatology and Venerology, AKM Allergiekongress, and the Austrian Food Chemical Society. B. Bohle has received research support from the Austrian Science Fund and the Christian Doppler Laboratory for Immunomodulation. The rest of the authors declare that they have no relevant conflicts of interest.