CB-058. REGULATION OF CANCER PROMOTING TRYPTOPHAN CATABOLISM IN GLIOBLASTOMA BY THE GLUCOCORTICOID RECEPTOR

The immunosuppressive microenvironment is a major obstacle for the treatment of glioblastoma. Recently, we identified a novel signaling pathway in glioblastoma and other types of cancer involving the degradation of tryptophan to kynurenine by tryptophan-2,3-dioxygenase (TDO), which leads to the inhi