A Genome-wide Search for Linkage to Asthma
1999
Abstract Asthma is among the most frequent chronic diseases in childhood. Although numerous environmental risk factors have already been identified, the basis for familial occurrence of asthma remains unclear. Previous genome screens for
atopyin British/Australian families and for asthma in different American populations showed inconsistent results. We report a sib pair study of a sample of 97 families, including 415 persons and 156 sib pairs. Following an extensive clinical evaluation, all participants were genotyped for 351 polymorphic dinucleotide markers. Linkage analysis for asthma identified four
chromosomal regionsthat could to be linked to asthma: chromosome 2 (at marker D2S2298, P = 0.007), chromosome 6 (around D6S291, lowest P = 0.008),
chromosome 9(proximal to D9S1784, P = 0.007), and
chromosome 12(D12S351, P = 0.010). These linkage regions could be reproduced for all loci by analysis of total or specific
immunoglobulin E(minimum P values at these regions were 0.003, 0.001, 0.010, and 0.015, respectively).
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