Trial of low molecular weight heparin in the treatment of viper bites.
2007
Aim of the Study: To study the efficacy of
low molecular weight heparin(LMWH) in the treatment of
viper
envenomationto combat the haematotoxicity and
disseminated intravascular coagulation(DIC). Methodology: Eighty patients with
viperbite and incoagulable blood were randomized into two groups of 40 each. One
group(
Testgroup) received LMWH, in addition to the antisnake venom (ASV) and other routine
measures receivedby the other group (Control group). Efficacy was assessed by monitoring the
bleeding time(BT), whole blood
clotting time(CT),
prothrombin time(PT), platelet count, fibrinogen, blood urea (BU), serum creatinine, development of complications and overall outcome. Results: LMWH group showed favourable outcome in all the parameters except in the incidence of renal failure which was reversible in the majority of the cases. However the differences between the two groups were statistically not significant. Conclusion: LMW heparin seems to have a beneficial role in the treatment of
viperbites, but this needs to be confirmed by a larger trial using a higher dose of heparin.
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