Deficiency of vitamin D and its relation with clinical and laboratory activity of inflammatory bowel diseases
2018
Abstract Objective To evaluate the serum concentrations of vitamin D and their relation with inflammatory bowel diseases. Methods This is a quantitative and descriptive study, with individuals assisted by the interdisciplinary ambulatory of Inflammatory Bowel Disease of the Family and Community Health Unit of Itajai/SC from September 2015 to October 2016. Socioeconomic data, life habits, and biochemical tests were collected, with the use of clinical indexes of classification of the disease activity: Harvey-Bradshaw Index (Crohn's Disease) and Partial Mayo Score (Chronic Nonspecific Ulcerative Colitis). Results Of the 60 patients evaluated, 57% ( n = 34) had Crohn's Disease and 43% ( n = 26) had Chronic Nonspecific Ulcerative Colitis. According to disease activity, 75% ( n = 45) were in the remission phase, 13% ( n = 8) had mild activity, and 9% ( n = 5) had moderate activity. Regarding vitamin D, 63% ( n = 38) had deficiency of this vitamin and 37% ( n = 22) presented sufficiency. With the association of serum vitamin D concentrations and disease activity, we observed statistical significance among the variables ( p = 0.005). Regarding biochemical exams, the majority of patients with fecal calprotectin elevation presented vitamin D deficiency ( p = 0.025). Statistically significant correlation between HSV and vitamin D ( p = 0.0001) was found. Conclusion According to the findings of this study, vitamin D deficiency is related to the clinical and laboratory activity of inflammatory bowel diseases.
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