A comparison of short term outcomes following Roux-en-Y Gastric Bypass in male and female patients using the MBSAQIP database

Abstract Background Male sex has long been identified as a risk factor for adverse outcomes, including mortality, after Roux-en-Y gastric bypass (RYGB). Objectives The objective of this study was to compare short-term outcomes of patients undergoing laparoscopic RYGB based on biologic sex. Methods Patients undergoing RYGB in the 2015, 2016 and 2017 Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program (MBSAQIP) database were propensity matched 1:1 to compare 30-day outcomes between male and female sex. Results A total 47,906 patients were included (23,953 Men/23,953 women). The overall complication rate was higher in female patients (11.5% vs. 10.2% p Conclusions Male sex has been identified as a risk factor for adverse events and mortality after RYGB in several risk models. This study demonstrates an overall increased risk of both all-cause mortality and inpatient mortality. The study, however did not demonstrate a difference in bariatric-related mortality. The prevalence of both major and minor complications was mixed between sexes while women had a higher overall complication rate after RYGB. The abundance of data available within the MBSAQIP Participant Use Data File (PUF) facilitates the creation of tools like risk models for bariatric surgery, such as the MBSAQIP Risk calculator.