Temporal changes in blood-brain barrier permeability and cerebral perfusion in lacunar/subcortical ischemic stroke

Background Cerebral microvascular abnormality is frequently associated with lacunarand subcortical ischemic lesions. We performed acute and follow-up CT perfusion scansover the first 3 months after ischemic stroke to investigate disturbances of the blood–brain barrier(BBB) and cerebral perfusion in patients with lacunar/subcortical lesions compared to those with cortical lesions alone.