Potyviruses differ in their requirement for TOR signalling
2015
Potyviruses are important plant pathogens that rely on many plant
cellular processesfor successful infection. TOR (target of rapamycin) signalling is a key eukaryotic energy-signalling pathway controlling many
cellular processessuch as translation and autophagy. The dependence of potyviruses on active
TOR signallingwas examined. Arabidopsis lines downregulated for TOR by RNAi were challenged with the potyviruses
watermelon mosaic virus(WMV) and
turnip mosaic virus(TuMV). WMV accumulation was found to be severely altered while TuMV accumulation was only slightly delayed. In another approach, using AZD-8055, an active site inhibitor of the TOR kinase, WMV infection was found to be strongly affected. Moreover, AZD-8055 application can cure WMV infection. In contrast, TuMV infection was not affected by AZD-8055. This suggests that potyviruses have different cellular requirements for active plant
TOR signalling.
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