Preferential expression of OVOL1 in inner root sheath of hair, sebaceous gland, eccrine duct and their neoplasms in human skin
2014
OVOL1 is an important transcription factor for epidermal keratinization, which suppresses proliferation and switches on the differentiation of keratinocytes. A recent
genome-wide association studyhas revealed that OVOL1 is one of the genes associated with susceptibility to atopic dermatitis. Although it is known to be expressed in murine skin and
hair follicles, no investigations have focused on its localization in
human skin. In the present study, we thus immunolocalized the expression of OVOL1 in normal and diseased
human skin. In normal
human skin, OVOL1 was preferentially expressed in the suprabasal layer of the epidermis,
inner root sheathof hair, mature sebocytes and the ductal portion of the
eccrine glands. Compared to this, no remarkable change in the expression of OVOL1 was observed among inflammatory skin diseases. The expression of OVOL1 was evident in
eccrine poromaand
hidradenoma. Moreover, it was overexpressed in
Bowen's diseaseand
sebaceous adenoma, in sharp contrast to its downregulation in their more malignant counterparts, squamous cell carcinoma and
sebaceous carcinoma. OVOL1 may play an important role in
human skinmorphogenesis and tumorigenesis.
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