Mesenteric venous thrombosis in a child with type 2 protein S deficiency.

A 5-year-old girl presented with abdominal pain and bloody stools2 weeks after suffering from influenza A infection. Enhanced computed tomographic scan showed widespread splanchnic venous thrombosisand small intestine necrosis. She recovered after the necrotic bowel was resected. The patient continues to receive anticoagulant therapy. Thrombophilia screening after the complete resolution consistently showed mildly decreased protein S(PS) activity with normal PS antigen levels. Sequence analysisdetected a heterozygous K196E mutation in the PROS1 gene. Type 2 PS deficiency was diagnosed. This is the first report of mesenteric vein thrombosisin a child with a type 2 PS deficiency.