From recognition to execution — the HCMV Pentamer from receptor binding to fusion triggering
2018
The β-herpesvirus
human cytomegalovirus(HCMV) is the leading viral cause of neonatal developmental disabilities. In HCMV, the conserved
herpesvirus glycoprotein B(gB) mediates membrane fusion between the viral and host cell membranes, whereas the trimeric gH/gL/gO or the pentameric gH/gL/UL128/UL130/UL31A complexes (
Pentamer) bind to cell-specific receptors and provide the triggering signal to gB. Recent structural and functional studies have provided new insights into
Pentamerstructure, conformational flexibility, location of epitopes for
neutralizing antibodiesand potential binding sites for
cell surface receptors. Together, these data suggest a model where receptor binding triggers a conformational change in
Pentamer, allowing it to interact with gB and initiate the membrane fusion process.
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