l-Carnitine improves cognitive and renal functions in a rat model of chronic kidney disease

Abstract Over the past decade, the prevalence of chronic kidney disease (CKD) has reached epidemic proportions. The search for novel pharmacological treatment for CKD has become an area of intensive clinical research. l - Carnitine, considered as the “ gatekeeper” responsible for admitting long chain fatty acidsinto cell mitochondria. l - Carnitinesynthesis and turnover are regulated mainly by the kidney and its levels inversely correlate with serum creatinine of normal subjects and CKD patients. Previous studies showed that l - carnitineadministration to elderly people is improving and preserving cognitive function. As yet, there are no clinical intervention studies that investigated the effect of l - carnitineadministration on cognitive impairment evidenced in CKD patients. Thus, we aimed to investigate the effects of l - carnitinetreatment on renal functionand on the cognitive performance in a rat model of progressive CKD. To assess the role of l - carnitineon CKD condition, we estimated the renal functionand cognitive abilities in a CKD rat model. We found that all CKD animals exhibited renal functiondeterioration, as indicated by elevated serum creatinine, BUN, and ample histopathological abnormalities. l - Carnitinetreatment of CKD rats significantly reduced serum creatinine and BUN, attenuated renal hypertrophy and decreased renal tissue damage. In addition, in the two way shuttle avoidance learning, CKD animals showed cognitive impairment which recovered by the administration of l - carnitine. We conclude that in a rat model of CKD, l - carnitineadministration significantly improved cognitive and renal functions.