A novel in situ multiplex immunofluorescence panel for the assessment of tumor immunopathology and response to virotherapy in pediatric glioblastoma reveals a role for checkpoint protein inhibition

Joshua D. Bernstock,Nunzio Vicario,Li Rong,Pablo A. Valdes,Bryan D. Choi,Jason A. Chen,Daniel DiToro,Diana S. Osorio,Kara Kachurak,Florian Gessler,James M. Johnston,T. Prescott Atkinson,Richard J. Whitley,Asim K. Bag,G. Yancey Gillespie,James M. Markert,Dragan Maric,Gregory K. Friedman

A novel in situ multiplex immunofluorescence panel for the assessment of tumor immunopathology and response to virotherapy in pediatric glioblastoma reveals a role for checkpoint protein inhibition

2019

Joshua D. Bernstock
Nunzio Vicario
Li Rong
Pablo A. Valdes
Bryan D. Choi
Jason A. Chen
Daniel DiToro
Diana S. Osorio
Kara Kachurak
Florian Gessler
James M. Johnston
T. Prescott Atkinson
Richard J. Whitley
Asim K. Bag
G. Yancey Gillespie
James M. Markert
Dragan Maric
Gregory K. Friedman

ABSTRACTImmunotherapy with oncolytic herpes simplex virus-1 therapy offers an innovative, targeted, less-toxic approach for treating brain tumors. However, a major obstacle in maximizing oncolytic ...

Keywords:

Immunofluorescence
Multiplex
Glioblastoma
Virotherapy
Glioma
Oncolytic virus
Immunopathology
Medicine
Cancer research
Immunotherapy
pediatric glioblastoma

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