Diffuse Pontine Astrocytoma With Lipocytic Differentiation
2012
A 7-year-old boy was treated with radiation and chemotherapy for a diffuse pontine glioma. At autopsy, 8 months after diagnosis, the tumor was a diffuse
gradeII
fibrillary astrocytomawith prominent lipocytic differentiation. Literature review suggests that lipocytic differentiation in
low-grade astrocytomasoccurs in a variety of patient ages, anatomic sites,
grades, and astrocytic subtypes. Although the majority of low-
gradelipoastrocytomas have behaved benignly, this child's lipoastrocytoma was the underlying cause of death. This outcome suggests that the outcomes of low-
gradelipoastrocytic tumors may be expected to be the same as the underlying tumor subtype.
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