In Vitro Activities of 10 Antifungal Drugs against 508 Dermatophyte Strains

We have tested 508 strains belonging to 24 species of dermatophytesagainst 10 antifungal drugsfollowing mainly the NCCLS (M38-P) standard for filamentous fungi. However, several important factors, such as the temperature (28 versus 35°C) and time of incubation (4 to 10 days versus 21 to 74 h), have been modified. The antifungalsused were itraconazole, ketoconazole, miconazole, clotrimazole, voriconazole, terbinafine, amphotericin B, fluconazole, UR-9825, and G-1. In general, with the exception of fluconazoleand G-1, all antifungalswere shown to be highly effective.